The Right Way to Use Medicated Shampoo on Locs (Most People Get This Wrong)

Medicated shampoos are special shampoos made to treat scalp problems like dandruff, Psoriasis and seborrheic dermatitis. They have ingredients that fight things like fungus, bacteria, or inflammation. Some common ones include:

  • Nizoral (ketoconazole) – for dandruff and fungal issues

  • T/Gel by Neutrogena (coal tar) – for scalp psoriasis and itching

  • Selsun Blue (selenium sulfide) – for dandruff and oily scalp

  • Head & Shoulders Clinical (pyrithione zinc) – for flaking and irritation

Using medicated shampoo the wrong way will not fix the problem and can lead to dry brittle hair. Here’s what most people miss:

  1. Medicated shampoo is for treating your scalp—not for regular washing.

  2. It is designed to go on your scalp—not your locs.

Now let’s talk about how to use it correctly.

1. Apply the Mixture Directly to Your Scalp Only

Your scalp is where the problem is, so that’s where the treatment should go. Use your fingers or to part your hair and apply the shampoo straight to your scalp and root. Avoid dispersing it all through your locs.

2. Massage Gently With Fingertips, Not Nails

Use the pads of your fingers to gently rub the shampoo into your scalp. Focus on areas that are itchy, flaky, or irritated. Check the label—most medicated shampoos need to sit for a few minutes to work properly.

3. Rinse Extra Thoroughly to Avoid Buildup

Rinse your scalp and locs with warm water for at least 2–3 minutes. Lift and separate your locs as you rinse to make sure nothing gets trapped inside. Leftover shampoo can cause scalp irritation, odor, or mildew over time.

4. Follow Up With Moisture

Medicated shampoos can cause dryness, so once your hair is clean, use a hydrating/moisturizing shampoo for a second wash, then follow up with a hydrating mist and seal with a lightweight oil to bring balance back.

Quick Tips:

  • Use medicated shampoo as directed to prevent condition from coming back

  • Never apply it to dry locs—wet them first

  • Focus on the scalp, not the locs

  • Let the medicated shampoo sit for a prescribed timeframe to reap the benefits. 

  • Rinse thoroughly to remove all traces of shampoo

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10 Things You Need to Know Before Starting Your Locs

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What to Expect for Your Starter Locs Consultation at Tresses Locs & Coils (Plus 10 Questions to Ask)